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Circadian Metabolism & Chronic Disease Management: The role of stress, meal timing and physical activity

Chronic disease is characterized by a gradual diminishing of the metabolic reserves that keep cells and tissues resilient against wear and dysfunction. Maintaining, and especially rebuilding, these reserves require that each system is working in optimal synchrony- something that cannot be accomplished without circadian co-ordination.

This three part workshop series outlines the fundamentals of circadian metabolism (central and peripheral clocks), with an emphasis on its modulation from the HPA axis, stress, meal timing and physical activity. Learn about the mechanisms that link these systems and discuss the evidence for how modulating these lifestyle inputs can benefit chronic disease outcomes.


Dr Thomas Guilliams, PhD
Nutritional Supplements Expert,
Educator & Researcher

Dr Guilliams earned his doctorate in molecular immunology from the Medical College of Wisconsin in Milwaukee. For the past twoo decades, he has spent his time investigating the mechanisms and actions of lifestyle and nutrient-based therapies and is an expert in the therapeutic uses of dietary supplements. Tom serves as an adjunct assistant professor at the University of Wisconsin- School of Pharmacy and was the VP of Science for Ortho Molecular Products for 24 years, where he now serves as a consultant. Tom is the author of a series of teaching manuals (The Standard Road Map Series) that outline and evaluate the evidence for the principles and protocols that are fundamental to the functional and integrative medicial community. He is the founder and director of the Point Institute, an independent research and publishing organisatio, a frequent international guest-speaker, providing training to a variety of healthcare disciplines in the use of lifestyle and natural medicines.

Dr Rhona Creegan, PhD
Nutritional Biochemist,
Nutritionist & A5M Educator

Dr Rhona is a nutritional biochemist, registered nutritionist, researcher, published author and regular educator for A5M & ACAAM. She has extensive experience in clinical biochemistry, molecular genetics and nutrition.
Dr Rhona has completed her Master’s degree in Nutrition Medicine and her key interests are abnormal lipid metabolism and metabolic dysfunction and key features of chronic disease and ageing.


  • SESSION 1: Circadian Mechanisns and the HPA Axis
  • SESSION 2: Circadian Mechanisms and the influence of meal timing and physical activity
  • SESSION 3: Intervention Strategies for Circadian Re-synchrony


  • Describe the basic features of central and peripheral clock mechanisms and the fundamental features of the HPA axis
  • Explain how day/light signalling throught the HPA axis and how cortisol interacts with peripheral clocks
  • Discuss how acute and chronic stress can affect metabolisn and circadian function
  • Expand on the purposes of the circadian metabolic system, its role in anticipating the need for nutrient absorption, physical activity and immune upregulation
  • Discuss time-related eating patterns (e.g. time-restricted feeding, fasting, breakfast skipping) and food quality on circadian function
  • Examine the effects of physical activity on circadian gene expression
  • The final session provides the principles and basic strategies for assessing a patient's circadian function, focusing of lifestyle inputs that reinforce circadian function such as:
    - stress assessment and management
    - sleep therapy, meal timing, and avoidance of circadian disruptors
    - inflammatory signals and nutrient interventions