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Circadian Metabolism & Chronic Disease Management: The role of stress, meal timing and physical activity
Chronic disease is characterized by a gradual diminishing of the metabolic reserves that keep cells and tissues resilient against wear and dysfunction. Maintaining, and especially rebuilding, these reserves require that each system is working in optimal synchrony- something that cannot be accomplished without circadian co-ordination.
This three part workshop series outlines the fundamentals of circadian metabolism (central and peripheral clocks), with an emphasis on its modulation from the HPA axis, stress, meal timing and physical activity. Learn about the mechanisms that link these systems and discuss the evidence for how modulating these lifestyle inputs can benefit chronic disease outcomes.
Dr Thomas Guilliams, PhD
Nutritional Supplements Expert,
Educator & Researcher
Dr Rhona Creegan, PhD
Nutritionist & A5M Educator
Dr Rhona has completed her Master’s degree in Nutrition Medicine and her key interests are abnormal lipid metabolism and metabolic dysfunction and key features of chronic disease and ageing.
- SESSION 1: Circadian Mechanisns and the HPA Axis
- SESSION 2: Circadian Mechanisms and the influence of meal timing and physical activity
- SESSION 3: Intervention Strategies for Circadian Re-synchrony
WORKSHOP LEARNING OBJECTIVES
- Describe the basic features of central and peripheral clock mechanisms and the fundamental features of the HPA axis
- Explain how day/light signalling throught the HPA axis and how cortisol interacts with peripheral clocks
- Discuss how acute and chronic stress can affect metabolisn and circadian function
- Expand on the purposes of the circadian metabolic system, its role in anticipating the need for nutrient absorption, physical activity and immune upregulation
- Discuss time-related eating patterns (e.g. time-restricted feeding, fasting, breakfast skipping) and food quality on circadian function
- Examine the effects of physical activity on circadian gene expression
- The final session provides the principles and basic strategies for assessing a patient's circadian function, focusing of lifestyle inputs that reinforce circadian function such as:
- stress assessment and management
- sleep therapy, meal timing, and avoidance of circadian disruptors
- inflammatory signals and nutrient interventions